Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 490411
Title Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration
Author(s) Emran, S.; Yang, M.Y.; He, X.L.; Zandveld, J.; Piper, M.D.W.
Source Aging-US 6 (2014)5. - ISSN 1945-4589 - p. 390 - 398.
DOI https://doi.org/10.18632/aging.100665
Department(s) Laboratory of Genetics
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) caenorhabditis-elegans - drosophila-melanogaster - longevity assurance - stress resistance - food restriction - fat storage - tor - extension - growth - yeast
Abstract Dietary restriction (DR), defined as a moderate reduction in food intake short of malnutrition, has been shown to extend healthy lifespan in a diverse range of organisms, from yeast to primates. Reduced signalling through the insulin/IGF-like (IIS) and Target of Rapamycin (TOR) signalling pathways also extend lifespan. In Drosophila melanogaster the lifespan benefits of DR can be reproduced by modulating only the essential amino acids in yeast based food. Here, we show that pharmacological downregulation of TOR signalling, but not reduced IIS, modulates the lifespan response to DR by amino acid alteration. Of the physiological responses flies exhibit upon DR, only increased body fat and decreased heat stress resistance phenotypes correlated with longevity via reduced TOR signalling. These data indicate that lowered dietary amino acids promote longevity via TOR, not by enhanced resistance to molecular damage, but through modified physiological conditions that favour fat accumulation.
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