Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 493583
Title Phylogenetic and Metabolic Tracking of Gut Microbiota during Perinatal Development
Author(s) Chierico, F. Del; Vernocchi, P.; Petrucca, A.; Paci, P.; Fuentes Enriquez de Salamanca, S.; Praticò, G.; Capuani, G.; Masotti, A.; Reddel, S.; Russo, A.; Vallone, C.; Salvatori, G.; Buffone, E.; Signore, F.; Rigon, G.; Dotta, A.; Miccheli, A.; Vos, W.M. de; Dallapiccola, B.; Putignani, L.
Source PLoS ONE 10 (2015)9. - ISSN 1932-6203 - 26 p.
DOI https://doi.org/10.1371/journal.pone.0137347
Department(s) Microbiology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2015
Abstract The colonization and development of gut microbiota immediately after birth is highly variable and depends on several factors, such as delivery mode and modality of feeding during the first months of life. A cohort of 31 mother and neonate pairs, including 25 at-term caesarean (CS) and 6 vaginally (V) delivered neonates (DNs), were included in this study and 121 meconium/faecal samples were collected at days 1 through 30 following birth. Operational taxonomic units (OTUs) were assessed in 69 stool samples by phylogenetic microarray HITChip and inter- and intra-individual distributions were established by inter-OTUs correlation matrices and OTUs co-occurrence or co-exclusion networks. 1H-NMR metabolites were determined in 70 stool samples, PCA analysis was performed on 55 CS DNs samples, and metabolome/OTUs co-correlations were assessed in 45 CS samples, providing an integrated map of the early microbiota OTUs-metabolome. A microbiota "core" of OTUs was identified that was independent of delivery mode and lactation stage, suggesting highly specialized communities that act as seminal colonizers of microbial networks. Correlations among OTUs, metabolites, and OTUs-metabolites revealed metabolic profiles associated with early microbial ecological dynamics, maturation of milk components, and host physiology
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