Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 501719
Title Transport and metabolism of fumaric acid in Saccharomyces cerevisiae in aerobic glucose-limited chemostat culture
Author(s) Shah, Mihir V.; Mastrigt, Oscar van; Heijnen, Joseph J.; Gulik, Walter M. van
Source Yeast 33 (2016)4. - ISSN 0749-503X - p. 145 - 161.
Department(s) Food Microbiology
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Fumaric acid - Futile cycling - Metabolism - Permeability coefficient - saccharomyces cerevisiae - Transport mechanism

Currently, research is being focused on the industrial-scale production of fumaric acid and other relevant organic acids from renewable feedstocks via fermentation, preferably at low pH for better product recovery. However, at low pH a large fraction of the extracellular acid is present in the undissociated form, which is lipophilic and can diffuse into the cell. There have been no studies done on the impact of high extracellular concentrations of fumaric acid under aerobic conditions in S. cerevisiae, which is a relevant issue to study for industrial-scale production. In this work we studied the uptake and metabolism of fumaric acid in S. cerevisiae in glucose-limited chemostat cultures at a cultivation pH of 3.0 (pH

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