Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 511491
Title Effects and detection of Nandrosol and ractopamine administration in veal calves
Author(s) Divari, Sara; Berio, Enrica; Pregel, Paola; Sereno, Alessandra; Chiesa, Luca; Pavlovic, Radmila; Panseri, Sara; Bovee, Toine F.H.; Biolatti, Bartolomeo; Cannizzo, Francesca T.
Source Food Chemistry 221 (2017). - ISSN 0308-8146 - p. 706 - 713.
DOI https://doi.org/10.1016/j.foodchem.2016.11.116
Department(s) BU Toxicology, Novel Foods & Agrochains
BU Authenticity & Bioassays
Publication type Refereed Article in a scientific journal
Publication year 2017
Keyword(s) Bioassay - Gene expression - Histopathology - LC-MS/MS - Nandrosol - Ractopamine - SARM - Veal calves
Abstract

The present study describes different effects of the selective androgen receptor modulator (SARM) nandrolone phenylpropionate (Nandrosol) and the β-agonist ractopamine administration in veal calves, and it investigates different strategies applied to trace these molecules. Morphological changes of gonads and accessory glands attributed to androgen effects, such as testicular atrophy, seminiferous tubule diameter reduction and hyperplasia of prostate epithelium, were detected, although SARMs are not described to cause these lesions. The gene expression analysis showed an anabolic activity of Nandrosol in Longissimus dorsi muscle, where myosin heavy chain (MYH) was significantly up-regulated. An IGF1 increase was weakly significant only in Vastus lateralis muscle. In conclusion, the anatomo-histopathological observations and the MYH mRNA up-regulation in Longissimus dorsi muscle confirm the androgenic treatment in experimental animals. The biosensor assay was not enough sensitive to detect residues in urines and only the direct chemical analysis of urine samples confirmed both β-agonist and SARM treatment.

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