Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 515065
Title reGenotyper: Detecting mislabeled samples in genetic data
Author(s) Zych, Konrad; Snoek, Basten L.; Elvin, Mark; Rodriguez, Miriam; Velde, K.J. Van Der; Arends, Danny; Westra, Harm-Jan; Swertz, Morris A.; Poulin, Gino; Kammenga, Jan E.; Breitling, Rainer; Jansen, Ritsert C.; Li, Yang
Source PLoS ONE 12 (2017)2. - ISSN 1932-6203
Department(s) Laboratory of Nematology
Publication type Refereed Article in a scientific journal
Publication year 2017
Abstract In high-throughput molecular profiling studies, genotype labels can be wrongly assigned at various experimental steps; the resulting mislabeled samples seriously reduce the power to detect the genetic basis of phenotypic variation. We have developed an approach to detect potential mislabeling, recover the “ideal” genotype and identify “best-matched” labels for mislabeled samples. On average, we identified 4% of samples as mislabeled in eight published datasets, highlighting the necessity of applying a “data cleaning” step before standard data analysis.
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