Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 519880
Title Correlation of carotid artery reactivity with cardiovascular risk factors and coronary artery vasodilator responses in asymptomatic, healthy volunteers
Author(s) Mil, Anke C.C.M. Van; Hartman, Yvonne; Oorschot, Frederieke Van; Heemels, Annemieke; Bax, Nikki; Dawson, Ellen A.; Hopkins, Nicola; Hopman, Maria T.E.; Green, Daniel J.; Oxborough, David L.; Thijssen, Dick H.J.
Source Journal of Hypertension 35 (2017)5. - ISSN 0263-6352 - p. 1026 - 1034.
DOI https://doi.org/10.1097/HJH.0000000000001274
Department(s) Human Nutrition & Health
Publication type Refereed Article in a scientific journal
Publication year 2017
Keyword(s) Cardiovascular risk - Carotid artery reactivity test - Cold pressor test - Coronary arteries - Endothelial function
Abstract Objectives: Carotid artery reactivity (CAR%), involving carotid artery diameter responses to a cold pressor test (CPT), is a noninvasive measure of conduit artery function in humans. This study examined the impact of age and cardiovascular risk factors on the CAR% and the relationship between CAR% and coronary artery vasodilator responses to the CPT. Methods: Ultrasound was used to measure resting and peak carotid artery diameters during the CPT, with CAR% being calculated as the relative change from baseline (%). We compared CAR% between young (n=50, 24±3 years) and older participants (n=44, 61±8 years), and subsequently assessed relationships between CAR% and traditional cardiovascular risk factors in 50 participants (44±21 years). Subsequently, we compared left anterior descending (LAD) artery velocity (using transthoracic Doppler) with carotid artery diameter (i.e. CAR%) during the CPT (n=33, 37±17 years). Results: A significantly larger CAR% was found in young versus older healthy participants (4.1±3.7 versus 1.8±2.6, P<0.001). Participants without cardiovascular risk factors demonstrated a higher CAR% than those with at least two risk factors (2.9±2.9 versus 0.5±2.9, P=0.019). Carotid artery diameter and LAD velocity increased during CPT (P<0.001). Carotid diameter and change in velocity correlated with LAD velocity (r=0.486 and 0.402, P<0.004 and 0.02, respectively). Conclusion: Older age and cardiovascular risk factors are related to lower CAR%, while CAR% shows good correlation with coronary artery responses to the CPT. Therefore, CAR% may represent a valuable technique to assess cardiovascular risk, while CAR% seems to reflect coronary artery vasodilator function.
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