Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 524098
Title Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants : A Randomized, Double-blind, Multicenter Study
Author(s) Chua, Mei Chin; Ben-Amor, Kaouther; Lay, Christophe; Neo, Anne G.E.; Chiang, Wei Chin; Rao, Rajeshwar; Chew, Charmaine; Chaithongwongwatthana, Surasith; Khemapech, Nipon; Knol, Jan; Chongsrisawat, Voranush
Source Journal of Pediatric Gastroenterology and Nutrition 65 (2017). - ISSN 0277-2116 - p. 102 - 106.
DOI https://doi.org/10.1097/MPG.0000000000001623
Department(s) Microbiology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2017
Keyword(s) Bifidobacterium breve M-16V - C-section - gut microbiota - prebiotics - probiotics - synbiotics
Abstract

We determined the effect of short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V on the gut microbiota of cesarean-born infants. Infants were randomized to receive a standard formula (control), the same with scGOS/lcFOS and B. breve M-16V (synbiotic), or with scGOS/lcFOS (prebiotic) from birth until week 16, 30 subjects born vaginally were included as a reference group. Synbiotic supplementation resulted in a higher bifidobacteria proportion from day 3/5 (P<0.0001) until week 8 (P=0.041), a reduction of Enterobacteriaceae from day 3/5 (P=0.002) till week 12 (P=0.016) compared to controls. This was accompanied with a lower fecal pH and higher acetate. In the synbiotic group, B. breve M-16V was detected 6 weeks postintervention in 38.7% of the infants. This synbiotic concept supported the early modulation of Bifidobacterium in C-section born infants that was associated with the emulation of the gut physiological environment observed in vaginally delivered infants.

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