Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 531358
Title Modelling the effects of ethanol on the solubility of the proteinogenic amino acids with the NRTL, Gude and Jouyban-Acree models
Author(s) Bowden, Nathan A.; Sevillano, David Mendez; Sanders, Johan P.M.; Bruins, Marieke E.
Source Fluid Phase Equilibria 459 (2018). - ISSN 0378-3812 - p. 158 - 169.
Department(s) Biobased Chemistry and Technology
Biobased Products
Food Technology
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Aqueous-solutions - Equilibria - Excess solubility - Organic solvents - Thermodynamics
Abstract The addition of organic solvents, such as ethanol, to molecules in solution is an effective process for crystallization and is used in industrial settings (i.e. pharmaceutical production, downstream processing, etc.). In this study, we use solubility data of all proteinogenic α-amino acids in binary ethanol/water systems to model their excess solubility. We use the empirical and regressive models of Gude and NRTL and the predictive Jouyban-Acree model. Based on the results, we hypothesize that amino acids that are spherical and lack a reactive side chain show little or no excess solubility. Being rod-like and/or having a reactive side chain leads to a positive excess solubility in a mixed solvent of ethanol and water. The empirical and regressed models, NRTL and Gude, fit the data well and the predictive Jouyban-Acree model, not originally intended to be used for small molecules, is less accurate but offers insights into the thermodynamic properties of the amino acids.
There are no comments yet. You can post the first one!
Post a comment
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.