Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 531377
Title Mucosal responses of healthy humans to exponentially growing or stationary Lactobacillus plantarum bacteria
Author(s) Baarlen, Peter van; Kleerebezem, Michiel; Brummer, Robert-Jan M.; Meer, Cindy van der; Hooiveld, Guido; Troost, Fred J.; Groot, Philip de
Source Wageningen University
Department(s) VLAG
Host-Microbe Interactomics
Human Nutrition & Health
Publication type Dataset
Publication year 2009
Keyword(s) GSE11355 - Homo sapiens - PRJNA106573 - GSE11355 - Homo sapiens - PRJNA106573
Abstract Some commensal bacteria stimulate the immune system but do not present specific antigenicity. Such adjuvant effects have been reported for the bacterial species Lactobacillus plantarum. To study in vivo human responses to L. plantarum, a randomised double-blind placebo-controlled cross-over study was performed. Healthy adults were provided preparations of living and heat-killed L. plantarum bacteria, biopsies were taken from the intestinal mucosa and altered transcriptional profiles were analysed. Transcriptional profiles of human epithelia displayed striking differences upon exposure to living L. plantarum bacteria harvested at different growth phases. Modulation of NF-κB-dependent pathways was central among the major altered cellular responses. This unique in vivo study shows which cellular pathways are associated with the induction of immune tolerance in mucosal tissues towards common adjuvanticity possessing lactobacilli.
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