Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 536541
Title A kaleidoscopic look at vanillyl alcohol oxidase
Author(s) Gygli, Gudrun
Source Wageningen University. Promotor(en): W.J.H. Berkel. - Wageningen : Wageningen University - ISBN 9789463437417 - 224
Department(s) Biochemistry
Publication type Dissertation, internally prepared
Publication year 2018

Vanillyl alcohol oxidase can make vanillin, the major flavour component of vanilla. We have studied this enzyme in great detail to better understand how it works and how exactly it produces vanillin. We have identified two different paths that guide substrates to where the reaction takes place. Once there, some substrates form an adduct, preventing product formation. Based on our work, we predict that the size of the substrate determines if the adduct is formed, and that one amino acid in the active centre of the enzyme is crucial for this process. Our work will help other researchers to improve this enzyme so that it can make vanillin more efficiently.

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