Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 539790
Title Access denied : A closer look at anti-phage defense mechanisms
Author(s) Vlot, Marnix
Source Wageningen University. Promotor(en): J. van der Oost, co-promotor(en): S.J.J. Brouns. - Wageningen : Wageningen University - ISBN 9789463437752 - 178
Department(s) Microbiology
Publication type Dissertation, internally prepared
Publication year 2018

Microorganisms are under constant threat by their viruses, bacteriophages (phages). In response to this pressure, they have developed multiple strategies to protect from phage infection. Mechanisms that protect microorganisms from phage infection include restriction-modification, BREX, DISARM, and CRISPR-Cas systems. However, phages have developed several mechanisms by which they can evade anti-phage defense systems. One common way to evade these systems by phages is by modifying their nucleic acids (DNA). This thesis encompasses the characterization of several CRISPR-Cas and DISARM proteins and studying the effect of phage DNA modifications on the activity of these proteins.

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