Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 542639
Title Akkermansia transcriptome response to mucin and/or glucose growth medium
Author(s) Ottman, N.A.; Davids, M.; Suarez Diez, M.; Boeren, J.A.; Schaap, P.J.; Martins dos Santos, V.A.P.; Smidt, H.; Belzer, C.; Vos, W.M. de
Department(s) Microbiology
Systems and Synthetic Biology
VLAG
Biochemistry
WIMEK
Publication type Dataset
Publication year 2017
Keyword(s) PRJEB9527 - ERP010638 - Akkermansia muciniphila
Abstract Transcriptome analysis comparing the gene expression of A. muciniphila grown on mucin or glucose media confirmed the activity of the genes involved in mucin degradation, and revealed most of them to be upregulated in the presence of mucin. A. muciniphila grown on glucose showed a stress response and upregulation of specific genes, such as Amuc_1094 which was identified as a glucokinase induced by glucose. The transcriptional response was confirmed by a proteome analysis, reinforcing the adaptation of A. muciniphila to the mucosal environment. These new findings provide molecular insights into the lifestyle of A. muciniphila, and further confirm its role as a mucin specialist in the gut.
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