Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 543299
Title Gut Microbiota and Body Weight in School-Aged Children : The KOALA Birth Cohort Study
Author(s) Mbakwa, Catherine A.; Hermes, Gerben D.A.; Penders, John; Savelkoul, Paul H.M.; Thijs, Carel; Dagnelie, Pieter C.; Mommers, Monique; Zoetendal, Erwin G.; Smidt, Hauke; Arts, Ilja C.W.
Source Obesity 26 (2018)11. - ISSN 1930-7381 - p. 1767 - 1776.
Department(s) Microbiology
Publication type Refereed Article in a scientific journal
Publication year 2018

Objective: This study aimed to examine the intestinal microbiota composition of school-aged children in association with (over)weight. Methods: The fecal microbiota composition of 295 children was analyzed using the Human Intestinal Tract Chip. Anthropometric outcomes (overweight [BMI ≥ 85th percentile], age- and sex-standardized BMI and weight z scores) were measured at 6 to 7 years of age, and elastic net was used to select genus-like bacterial groups related to all anthropometric outcomes. Subsequently, multiple linear and logistic regression models were used to model associations between selected bacterial groups and anthropometric measures while controlling for confounders. Results: Prevotella melaninogenica, Prevotella oralis, Dialister, and uncultured Clostridiales II (UCII) accounted for 26.1% of the variation in microbiota composition. Several bacterial groups were inversely associated with the anthropometric outcomes: Sutterella wadsworthensis, Marvinbryantia formatexigens, Prevotella melanogenica, P oralis, Burkholderia, uncultured Clostridiales II, and Akkermansia, while Streptococcus bovis was positively associated with overweight. Microbial diversity and richness, and Bacteroidetes to Firmicutes ratio, were not significantly associated with any of the outcomes. Conclusions: In the largest population-based study on childhood gut microbiota and body weight so far, both new and previously identified bacterial groups were found to be associated with overweight. Further research should elucidate their role in energy metabolism.

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