Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 543964
Title Cyclodextrin-based complex coacervate core micelles with tuneable supramolecular host–guest, metal-to-ligand and charge interactions
Author(s) Facciotti, Camilla; Saggiomo, Vittorio; Bunschoten, Anton; Fokkink, Remco; Hove, Jan Bart Ten; Wang, Junyou; Velders, Aldrik H.
Source Soft Matter 14 (2018)47. - ISSN 1744-683X - p. 9542 - 9549.
DOI https://doi.org/10.1039/C8SM01504J
Department(s) BioNanoTechnology
VLAG
Physical Chemistry and Soft Matter
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract Micelles have been recognized as versatile platforms for different biomedical applications, from bioimaging to drug delivery. Complex coacervate core micelles present great advantages compared to traditional micelles, however controlling the number of charges per core-unit and the stability is still a challenge. We here present cyclodextrin-based complex coacervate core micelles where the charge per core-unit can be straightforwardly tuned by cyclodextrin host–guest interactions. By varying the ratio between two adamantane guest molecules, 1-adamantanecarboxylic acid and 1,3-adamantanediacetic acid, the charge of the monomeric core-units can be finely tuned from 6− to 9−. By adding an adamantane bislinker, monomeric core-units can be combined together in dimeric and polymeric structures, increasing the micelles’ stability. The orthogonal supramolecular host–guest and coordination-chemistry allows for well-controlled cyclodextrin-based complex coacervate core micelles that offer a versatile platform for designing future, e.g., responsive systems.
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