Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 545327
Title Receptomics: Calcium imaging of sensory receptor cell arrays in a microfluidic system and novel applications for food screening
Author(s) Roelse, M.; Henquet, M.G.L.; Jongsma, M.A.
Department(s) BIOS Applied Metabolic Systems
Publication type Poster (scientific)
Publication year 2018
Abstract Reverse-transfected cell arrays in microfluidic systems have strong potential to perform large-scale parallel screening of GPCR libraries. We have successfully combined the multi-variable nature of a receptor cell array with microfluidics allowing for controlled and sequential sample dosing [1]. Our receptomics platform uniquely allows for dosing of small sample quantities against a large receptor library including controls for host cell responses and sample colour. Compared to existing microtiter-plate systems it can be applied more efficiently for the screening of off-target effects and the discovery of bioactivities in complex extracts with strong and variable host cell responses. The sequential injection format allowed the development of powerful spot-based statistical models to discriminate between a host cell response and the superimposed specific GPCR response.
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