Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 545430
Title Mining bacterial genomes to reveal secret synergy
Author(s) Alanjary, Mohammad; Medema, Marnix H.
Source Journal of Biological Chemistry 293 (2018)52. - ISSN 0021-9258 - p. 19996 - 19997.
DOI https://doi.org/10.1074/jbc.H118.006669
Department(s) Bioinformatics
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract

The medical treatment of infectious diseases often requires combination therapies that blend two molecules to enhance drug efficacy. Nature does the same. In a new article, Mrak et al. identify and functionally characterize natural products from Streptomyces rapamycinicus that show synergistic antifungal activity with the well-known immunosuppressant metabolite rapamycin, produced by the same strain. The genomic co-association of the two biosynthetic gene clusters paves the way toward new strategies to discover synergistic pairs of antibiotics through large-scale genome mining.

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