Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 545968
Title Use of proteomics to detect sex-related differences in effects of toxicants : implications for using proteomics in toxicology
Author(s) Rietjens, Ivonne M.C.M.; Vervoort, Jacques; Maslowska-Górnicz, Anna; Brink, Nico Van den; Beekmann, Karsten
Source Critical Reviews in Toxicology 48 (2018)8. - ISSN 1040-8444 - p. 666 - 681.
DOI https://doi.org/10.1080/10408444.2018.1509941
Department(s) WIMEK
VLAG
Toxicology
Biochemistry
Systems and Synthetic Biology
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) mode of action - proteomics - Sex related differences - state-of-the-art - toxicants
Abstract

This review provides an overview of results obtained when using proteome analysis for detecting sex-based differences in response to toxicants. It reveals implications to be taken into account when considering the use of proteomics in toxicological studies. It appears that results may differ when studying the same chemical in the same species in different target tissues. Another result of interest is the limited dose-response behavior of differential abundance patterns observed in studies where more than one dose level is tested. It is concluded that use of proteomics to study differences in modes of action of toxic compounds is an active area of research. The examples from use of proteomics to study sex-dependent differences also reveal that further studies are needed to provide reliable insight in modes of action, novel biomarkers or even novel therapies. To eventually reach this aim for this and other toxicological endpoints, it is essential to consider background variability, consequences of timing of toxicant administration, dose-response behavior, relevant species and target organ, species and organ variability and the presence of proteoforms.

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