Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 546017
Title Meiotic drive of female-inherited supernumerary chromosomes in a pathogenic fungus
Author(s) Habig, Michael; Kema, Gert Hj; Holtgrewe Stukenbrock, Eva
Source eLife 7 (2018). - ISSN 2050-084X - 20 p.
DOI https://doi.org/10.7554/eLife.40251
Department(s) Biointeractions and Plant Health
Laboratory of Phytopathology
EPS
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) accessory chromosome - B chromosome - chromosomes - gene expression - genetics - genomics - meiotic drive - selfish genetic elements - tetrad analysis - Zymoseptoria tritici
Abstract

Meiosis is a key cellular process of sexual reproduction that includes pairing of homologous sequences. In many species however, meiosis can also involve the segregation of supernumerary chromosomes, which can lack a homolog. How these unpaired chromosomes undergo meiosis is largely unknown. In this study we investigated chromosome segregation during meiosis in the haploid fungus Zymoseptoria tritici that possesses a large complement of supernumerary chromosomes. We used isogenic whole chromosome deletion strains to compare meiotic transmission of chromosomes when paired and unpaired. Unpaired chromosomes inherited from the male parent as well as paired supernumerary chromosomes in general showed Mendelian inheritance. In contrast, unpaired chromosomes inherited from the female parent showed non-Mendelian inheritance but were amplified and transmitted to all meiotic products. We concluded that the supernumerary chromosomes of Z. tritici show a meiotic drive and propose an additional feedback mechanism during meiosis, which initiates amplification of unpaired female-inherited chromosomes.

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