Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 546601
Title Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food
Author(s) Knutsen, Helle Katrine; Alexander, Jan; Barregård, Lars; Bignami, Margherita; Brüschweiler, Beat; Ceccatelli, Sandra; Cottrill, Bruce; Dinovi, Michael; Edler, Lutz; Grasl‐Kraupp, Bettina; Hogstrand, Christer; Hoogenboom, Laurentius; Nebbia, Carlo Stefano; Oswald, Isabelle P.; Petersen, Annette; Rose, Martin; Roudot, Alain-Claude; Vleminckx, Christiane; Vollmer, Günter; Wallace, Heather; Bodin, Laurent; Cravedi, Jean-Pierre; Halldorsson, Thorhallur Ingi; Haug, Line Småstuen; Johansson, Niklas; Loveren, Henk van; Gergelova, Petra; Mackay, Karen; Levorato, Sara; Manen, Mathijs van; Schwerdtle, Tanja
Source EFSA Journal 16 (2018)12. - ISSN 1831-4732
DOI https://doi.org/10.2903/j.efsa.2018.5194
Department(s) BU Toxicology, Novel Foods & Agrochains
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract The European Commission asked EFSA for a scientific evaluation on the risks to human health related to the presence of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in food. Regarding PFOS and PFOA occurrence, the final data set available for dietary exposure assessment contained a total of 20,019 analytical results (PFOS n = 10,191 and PFOA n = 9,828). There were large differences between upper and lower bound exposure due to analytical methods with insufficient sensitivity. The CONTAM Panel considered the lower bound estimates to be closer to true exposure levels. Important contributors to the lower bound mean chronic exposure were ‘Fish and other seafood’, ‘Meat and meat products’ and ‘Eggs and egg products’, for PFOS, and ‘Milk and dairy products’, ‘Drinking water’ and ‘Fish and other seafood’ for PFOA. PFOS and PFOA are readily absorbed in the gastrointestinal tract, excreted in urine and faeces, and do not undergo metabolism. Estimated human half‐lives for PFOS and PFOA are about 5 years and 2–4 years, respectively. The derivation of a health‐based guidance value was based on human epidemiological studies. For PFOS, the increase in serum total cholesterol in adults, and the decrease in antibody response at vaccination in children were identified as the critical effects. For PFOA, the increase in serum total cholesterol was the critical effect. Also reduced birth weight (for both compounds) and increased prevalence of high serum levels of the liver enzyme alanine aminotransferase (ALT) (for PFOA) were considered. After benchmark modelling of serum levels of PFOS and PFOA, and estimating the corresponding daily intakes, the CONTAM Panel established a tolerable weekly intake (TWI) of 13 ng/kg body weight (bw) per week for PFOS and 6 ng/kg bw per week for PFOA. For both compounds, exposure of a considerable proportion of the population exceeds the proposed TWIs.
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