Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 546752
Title Individual human phenotypes in metabolic space and time
Author(s) Bernini, Patrizia; Bertini, Ivano; Luchinat, Claudio; Nepi, Stefano; Saccenti, Edoardo; Schäfer, Hartmut; Schütz, Birk; Spraul, Manfred; Tenori, Leonardo
Source Journal of Proteome Research 8 (2009)9. - ISSN 1535-3893 - p. 4264 - 4271.
DOI https://doi.org/10.1021/pr900344m
Department(s) VLAG
Systems and Synthetic Biology
Publication type Refereed Article in a scientific journal
Publication year 2009
Keyword(s) Gut microflora metabolites - Human metabolites - Individual metabolic fingerprint - Metabolomics - NMR spectroscopy - Principal component analysis
Abstract

Differences between individual phenotypes are due both to differences in genotype and to exposure to different environmental factors. A fundamental contribution to the definition of the individual phenotype for clinical and therapeutic applications would come from a deeper understanding of the metabolic phenotype. The existence of unique individual metabolic phenotypes has been hypothesized, but the experimental evidence has been only recently collected. Analysis of individual phenotypes over the timescale of years shows that the metabolic phenotypes are largely invariant. The present work also supports the idea that the individual metabolic phenotype can also be considered a metagenomic entity that is strongly affected by both gut microbiome and host metabolic phenotype, the latter defined by both genetic and environmental contributions.

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