Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 546765
Title Functional Annotation of Animal Genomes (FAANG): Current Achievements and Roadmap
Author(s) Giuffra, Elisabetta; Tuggle, Christopher K.; Groenen, M.
Source Annual Review of Animal Biosciences 7 (2018). - ISSN 2165-8102 - p. 13.1 - 13.24.
DOI https://doi.org/10.1146/annurev-animal-020518-114913
Department(s) WIAS
Animal Breeding and Genomics
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract Functional annotation of genomes is a prerequisite for contemporary basic
and applied genomic research, yet farmed animal genomics are deficient
in such annotation. To address this, the FAANG (Functional Annotation
of Animal Genomes) Consortium is producing genome-wide data sets on
RNA expression, DNA methylation, and chromatin modification, as well as
chromatin accessibility and interactions. In addition to informing our understanding of genome function, including comparative approaches to elucidate constrained sequence or epigenetic elements, these annotation maps
will improve the precision and sensitivity of genomic selection for animal
improvement. A scientific community–driven effort has already created a
coordinated data collection and analysis enterprise crucial for the success of
this global effort. Although it is early in this continuing process, functional
data have already been produced and application to genetic improvement
reported. The functional annotation delivered by the FAANG initiative will
add value and utility to the greatly improved genome sequences being established for domesticated animal species.
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