Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 547066
Title The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls
Author(s) Jalanka, Jonna; Major, Giles; Murray, Kathryn; Singh, Gulzar; Nowak, Adam; Kurtz, Caroline; Silos-Santiago, Inmaculada; Johnston, Jeffrey M.; Vos, Willem M. de; Spiller, Robin
Source International Journal of Molecular Sciences 20 (2019)2. - ISSN 1661-6596
DOI https://doi.org/10.3390/ijms20020433
Department(s) WIMEK
VLAG
Microbiology
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) constipation - ispaghula - microbiome - prebiotics - transit
Abstract

Psyllium is a widely used treatment for constipation. It traps water in the intestine increasing stool water, easing defaecation and altering the colonic environment. We aimed to assess the impact of psyllium on faecal microbiota, whose key role in gut physiology is being increasingly recognised. We performed two randomised, placebo-controlled, double-blinded trials comparing 7 days of psyllium with a placebo (maltodextrin) in 8 healthy volunteers and 16 constipated patients respectively. We measured the patients' gastrointestnal (GI) transit, faecal water content, short-chain fatty acid (SCFA) and the stool microbiota composition. While psyllium supplement had a small but significant effect on the microbial composition of healthy adults (increasing Veillonella and decreasing Subdoligranulum), in constipated subjects there were greater effects on the microbial composition (increased Lachnospira, Faecalibacterium, Phascolarctobacterium, Veillonella and Sutterella and decreased uncultured Coriobacteria and Christensenella) and alterations in the levels of acetate and propionate. We found several taxa to be associated with altered GI transit, SCFAs and faecal water content in these patients. Significant increases in three genera known to produce butyrate, Lachnospira, Roseburia and Faecalibacterium, correlated with increased faecal water. In summary, psyllium supplementation increased stool water and this was associated with significant changes in microbiota, most marked in constipated patients.

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