Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 547377
Title Detection of candidate regions affecting bovine IgM natural antibodies in milk
Author(s) Cordero Solorzano, Juan; Arts, J.A.J.; Parmentier, H.K.; Bovenhuis, H.
Source In: Proceedings of the World Congress on Genetics Applied to Livestock Production. - WCGALP - 8 p.
Event 11th World Congress on Genetics Applied to Livestock Production, Auckland, 2018-02-11/2018-02-16
Department(s) Animal Breeding and Genomics
Adaptation Physiology
Publication type Contribution in proceedings
Publication year 2018
Abstract Two genomic regions were found to be associated with IgM antibody titers in milk binding lipoteichoic acid (LTA); one on chromosome 17 and the other on chromosome 21. Phenotypes were measured by ELISA and genotypes consisted of imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. In BTA21, a gene for the heavy chains of immunoglobulins, IGHV is proposed as a candidate gene as was true for VPREB3 in BTA17 related to B-cell maturation. These findings provide a further step in better understanding the genetic background of natural antibodies (NAbs), that may be relevant for relevant for the estimation of dairy cattle health. Keywords: dairy cattle, natural antibodies, genome-wide association
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