Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 547951
Title Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study
Author(s) Santoro, Aurelia; Guidarelli, Giulia; Ostan, Rita; Giampieri, Enrico; Fabbri, Cristina; Bertarelli, Claudia; Nicoletti, Claudio; Kadi, Fawzi; Groot, Lisette C.P.G.M. De; Feskens, Edith; Berendsen, Agnes; Brzozowska, Anna; Januszko, Olga; Kozlowska, Katarzyna; Fairweather-Tait, Susan; Jennings, Amy; Meunier, Nathalie; Caumon, Elodie; Napoli, Alessandro; Mercatelli, Daniele; Battista, Giuseppe; Capri, Miriam; Franceschi, Claudio; Bazzocchi, Alberto
Source European Radiology 29 (2019)9. - ISSN 0938-7994 - p. 4968 - 4979.
DOI https://doi.org/10.1007/s00330-018-5973-2
Department(s) VLAG
Global Nutrition
Human Nutrition & Health
Publication type Refereed Article in a scientific journal
Publication year 2019
Abstract ObjectivesThe aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans. Methods A whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65–79 years) women and men from five European countries of the “New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe” project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-β1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays. Results BC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, glycoprotein 130, TNF-α-R1, and TNF-α-R2.Conclusions The association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice.
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