Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 548030
Title Phylogeographic distribution of human and hare Francisella tularenses susp. holarctica strains in the Netherlands and its pathology in European brown hares (Lepus europaeus)
Author(s) Koene, M.G.J.; Rijks, Jolianne M.; Maas, Miriam; Ruuls, R.C.; Engelsma, M.Y.; Tulden, P.W. van; Kik, Marja; IJzer, Jooske; Notermans, Daan; Vries, Maaike de; Fanoy, Ewout; Pijnacker, Roan; Spierenburg, Marcel A.H.; Bavelaar, Herjan; Berkhout, Hanneke; Sankatsing, Sanjay; Diepersloot, Rob; Myrtennas, Kerstin; Granberg, Malin; Forsman, Mats; Roest, H.I.J.; Gröne, Andrea
Source Frontiers in Cellular and Infection Microbiology 9 (2019). - ISSN 2235-2988 - 11 p.
DOI https://doi.org/10.3389/fcimb.2019.00011
Department(s) Bacteriology & Epidemiology
Diagnostics & Crisis Organization
Publication type Refereed Article in a scientific journal
Publication year 2019
Abstract Sequence-based typing of Francisella tularensis has led to insights in the evolutionary developments of tularemia. In Europe, two major basal clades of F. tularensis subsp. holarctica exist, with a distinct geographical distribution. Basal clade B.6 is primarily found in Western Europe, while basal clade B.12 occurs predominantly in the central and eastern parts of Europe. There are indications that tularemia is geographically expanding and that strains from the two clades might differ in pathogenicity, with basal clade B.6 strains being potentially more virulent than basal clade B.12. This study provides information on genotypes detected in the Netherlands during 2011–2017. Data are presented for seven autochthonous human cases and for 29 European brown hares (Lepus europaeus) with laboratory confirmed tularemia. Associated disease patterns are described for 25 European brown hares which underwent post-mortem examination. The basal clades B.6 and B.12 are present both in humans and in European brown hares in the Netherlands, with a patchy geographical distribution. For both genotypes the main pathological findings in hares associated with tularemia were severe (sub)acute necrotizing hepatitis and splenitis as well as necrotizing lesions and hemorrhages in several other organs. Pneumonia was significantly more common in the B.6 than in the B.12 cases. In conclusion, the two major basal clades present in different parts in Europe are both present in the Netherlands. In hares found dead, both genotypes were associated with severe acute disease affecting multiple organs. Hepatitis and splenitis were common pathological findings in hares infected with either genotype, but pneumonia occurred significantly more frequently in hares infected with the B.6 genotype compared to hares infected with the B.12 genotype.
Comments
There are no comments yet. You can post the first one!
Post a comment
 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.