Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 548167
Title Modelling aggregate exposure to pesticides from dietary and crop spray sources in UK residents
Author(s) Kennedy, Marc C.; Garthwaite, David G.; Boer, Waldo J. de; Kruisselbrink, Johannes W.
Source Environmental Science and Pollution Research 26 (2019)10. - ISSN 0944-1344 - p. 9892 - 9907.
DOI https://doi.org/10.1007/s11356-019-04440-7
Department(s) Biometris
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Cumulative assessment group - Non-dietary exposure - Pesticide usage survey - Simulation model - Uncertainty
Abstract

Human exposure to pesticide mixtures can occur from the diet and other sources. Realistic exposure and risk assessments should include multiple sources and compounds and include the relative hazards of the different compounds. The EU-funded Euromix project is developing new web-based tools to facilitate these calculations. A case study is presented that exemplifies their use for a population of UK residents, including exposure from crop-spraying. A UK pesticide usage survey provided information on real pesticide combinations applied to crops of wheat, potatoes, sugar beet and dessert apples. This information was combined with outputs from two alternative simulation models of spray drift to estimate dermal, oral and inhalation exposures of residents. These non-dietary exposures were combined with dietary exposure estimates using the Monte Carlo Risk Assessment software to produce a distribution of aggregated and cumulative exposures. Compounds are weighted by relative potency to generate a measure of overall risk. Uncertainty quantification was also included in the distribution of exposures. These tools are flexible to allow diverse sources of exposure and can provide important information to decision-makers and help to prioritise testing of pesticide mixtures. Including non-dietary sources changed the prioritisation of pesticide mixtures, when compared to dietary exposure alone.

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