Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 548180
Title Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood : An individual participant data meta-analysis
Author(s) Voerman, Ellis; Santos, Susana; Patro Golab, Bernadeta; Amiano, Pilar; Ballester, Ferran; Barros, Henrique; Bergström, Anna; Charles, Marie Aline; Chatzi, Leda; Chevrier, Cécile; Chrousos, George P.; Corpeleijn, Eva; Costet, Nathalie; Crozier, Sarah; Devereux, Graham; Eggesbø, Merete; Ekström, Sandra; Fantini, Maria Pia; Farchi, Sara; Forastiere, Francesco; Georgiu, Vagelis; Godfrey, Keith M.; Gori, Davide; Grote, Veit; Hanke, Wojciech; Hertz-Picciotto, Irva; Heude, Barbara; Hryhorczuk, Daniel; Huang, Rae Chi; Inskip, Hazel; Iszatt, Nina; Karvonen, Anne M.; Kenny, Louise C.; Koletzko, Berthold; Küpers, Leanne K.; Lagström, Hanna; Lehmann, Irina; Magnus, Per; Majewska, Renata; Mäkelä, Johanna; Manios, Yannis; McAuliffe, Fionnuala M.; McDonald, Sheila W.; Mehegan, John; Mommers, Monique; Morgen, Camilla S.; Mori, Trevor A.; Moschonis, George; Murray, Deirdre; Chaoimh, Carol Ní; Nohr, Ellen A.; Nybo Andersen, Anne Marie; Oken, Emily; Oostvogels, Adriëtte J.J.M.; Pac, Agnieszka; Papadopoulou, Eleni; Pekkanen, Juha; Pizzi, Costanza; Polanska, Kinga; Porta, Daniela; Richiardi, Lorenzo; Rifas-Shiman, Sheryl L.; Ronfani, Luca; Santos, Ana C.; Standl, Marie; Stoltenberg, Camilla; Thiering, Elisabeth; Thijs, Carel; Torrent, Maties; Tough, Suzanne C.; Trnovec, Tomas; Turner, Steve; Rossem, Lenie van; Berg, Andrea von; Vrijheid, Martine; Vrijkotte, Tanja G.M.; West, Jane; Wijga, Alet; Wright, John; Zvinchuk, Oleksandr; Sørensen, Thorkild I.A.; Lawlor, Debbie A.; Gaillard, Romy; Jaddoe, Vincent W.V.
Source PLOS Medicine 16 (2019)2. - ISSN 1549-1676 - p. e1002744 - e1002744.
DOI https://doi.org/10.1371/journal.pmed.1002744
Department(s) Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2019
Abstract

BACKGROUND: Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. METHODS AND FINDINGS: We conducted an individual participant data meta-analysis of data from 162,129 mothers and their children from 37 pregnancy and birth cohort studies from Europe, North America, and Australia. We assessed the individual and combined associations of maternal pre-pregnancy BMI and gestational weight gain, both in clinical categories and across their full ranges, with the risks of overweight/obesity in early (2.0-5.0 years), mid (5.0-10.0 years) and late childhood (10.0-18.0 years), using multilevel binary logistic regression models with a random intercept at cohort level adjusted for maternal sociodemographic and lifestyle-related characteristics. We observed that higher maternal pre-pregnancy BMI and gestational weight gain both in clinical categories and across their full ranges were associated with higher risks of childhood overweight/obesity, with the strongest effects in late childhood (odds ratios [ORs] for overweight/obesity in early, mid, and late childhood, respectively: OR 1.66 [95% CI: 1.56, 1.78], OR 1.91 [95% CI: 1.85, 1.98], and OR 2.28 [95% CI: 2.08, 2.50] for maternal overweight; OR 2.43 [95% CI: 2.24, 2.64], OR 3.12 [95% CI: 2.98, 3.27], and OR 4.47 [95% CI: 3.99, 5.23] for maternal obesity; and OR 1.39 [95% CI: 1.30, 1.49], OR 1.55 [95% CI: 1.49, 1.60], and OR 1.72 [95% CI: 1.56, 1.91] for excessive gestational weight gain). The proportions of childhood overweight/obesity prevalence attributable to maternal overweight, maternal obesity, and excessive gestational weight gain ranged from 10.2% to 21.6%. Relative to the effect of maternal BMI, excessive gestational weight gain only slightly increased the risk of childhood overweight/obesity within each clinical BMI category (p-values for interactions of maternal BMI with gestational weight gain: p = 0.038, p < 0.001, and p = 0.637 in early, mid, and late childhood, respectively). Limitations of this study include the self-report of maternal BMI and gestational weight gain for some of the cohorts, and the potential of residual confounding. Also, as this study only included participants from Europe, North America, and Australia, results need to be interpreted with caution with respect to other populations. CONCLUSIONS: In this study, higher maternal pre-pregnancy BMI and gestational weight gain were associated with an increased risk of childhood overweight/obesity, with the strongest effects at later ages. The additional effect of gestational weight gain in women who are overweight or obese before pregnancy is small. Given the large population impact, future intervention trials aiming to reduce the prevalence of childhood overweight and obesity should focus on maternal weight status before pregnancy, in addition to weight gain during pregnancy.

Comments
There are no comments yet. You can post the first one!
Post a comment
 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.