Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 548181
Title Symposium 2 : Nutrient interactions and their role in protection from chronic diseases: β-Carotene in the human body: Metabolic bioactivation pathways - From digestion to tissue distribution and excretion
Author(s) Bohn, Torsten; Desmarchelier, Charles; El, Sedef N.; Keijer, Jaap; Schothorst, Evert Van; Rühl, Ralph; Borel, Patrick
Source Proceedings of the Nutrition Society 78 (2019)1. - ISSN 0029-6651 - p. 68 - 87.
DOI https://doi.org/10.1017/S0029665118002641
Department(s) WIAS
VLAG
Human and Animal Physiology
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Absorption - Apo-carotenoids - Micellisation - Nuclear hormone receptor - Retinoic acid - SNPs - Vitamin A
Abstract

β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Further bioactive carotenoid-metabolites can modulate the expression of specific genes mainly via the nuclear hormone receptors: retinoic acid receptor- and retinoid X receptor-mediated signalling. To better understand the metabolic conversion of β-carotene, inter-individual differences regarding β-carotene bioavailability and bioactivity are key steps that determine its further metabolism and bioactivation and mediated signalling. Major carotenoid metabolites, the retinoids, can be stored as esters or further oxidised and excreted via phase 2 metabolism pathways. In this review, we aim to highlight the major critical control points that determine the fate of β-carotene in the human body, with a special emphasis on β-carotene oxygenase 1. The hypothesis that higher dietary β-carotene intake and serum level results in higher β-carotene-mediated signalling is partly questioned. Alternative autoregulatory mechanisms in β-carotene / retinoid-mediated signalling are highlighted to better predict and optimise nutritional strategies involving β-carotene-related health beneficial mediated effects.

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