Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 548319
Title Limited contribution of non-intensive chicken farming to ESBL-producing Escherichia coli colonization in humans in Vietnam : an epidemiological and genomic analysis
Author(s) Nguyen, Vinh Trung; Jamrozy, Dorota; Matamoros, Sébastien; Carrique-Mas, Juan J.; Ho, Huynh Mai; Thai, Quoc Hieu; Nguyen, Thi Nhu Mai; Wagenaar, Jaap A.; Thwaites, Guy; Parkhill, Julian; Schultsz, Constance; Ngo, Thi Hoa
Source Journal of Antimicrobial Chemotherapy 74 (2019)3. - ISSN 0305-7453 - p. 561 - 570.
DOI https://doi.org/10.1093/jac/dky506
Department(s) Bacteriology & Epidemiology
Publication type Refereed Article in a scientific journal
Publication year 2019
Abstract

OBJECTIVES: To investigate the risk of colonization with ESBL-producing Escherichia coli (ESBL-Ec) in humans in Vietnam associated with non-intensive chicken farming. METHODS: Faecal samples from 204 randomly selected farmers and their chickens, and from 306 age- and sex-matched community-based individuals who did not raise poultry were collected. Antimicrobial usage in chickens and humans was assessed by medicine cabinet surveys. WGS was employed to obtain a high-resolution genomic comparison between ESBL-Ec isolated from humans and chickens. RESULTS: The adjusted prevalence of ESBL-Ec colonization was 20.0% (95% CI 10.8%-29.1%) and 35.2% (95% CI 30.4%-40.1%) in chicken farms and humans in Vietnam, respectively. Colonization with ESBL-Ec in humans was associated with antimicrobial usage (OR = 2.52, 95% CI = 1.08-5.87) but not with involvement in chicken farming. blaCTX-M-55 was the most common ESBL-encoding gene in strains isolated from chickens (74.4%) compared with blaCTX-M-27 in human strains (47.0%). In 3 of 204 (1.5%) of the farms, identical ESBL genes were detected in ESBL-Ec isolated from farmers and their chickens. Genomic similarity indicating recent sharing of ESBL-Ec between chickens and farmers was found in only one of these farms. CONCLUSIONS: The integration of epidemiological and genomic data in this study has demonstrated a limited contribution of non-intensive chicken farming to ESBL-Ec colonization in humans in Vietnam and further emphasizes the importance of reducing antimicrobial usage in both human and animal host reservoirs.

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