Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 548377
Title Long-term impact of oral vancomycin, ciprofloxacin and metronidazole on the gut microbiota in healthy humans
Author(s) Haak, Bastiaan W.; Lankelma, Jacqueline M.; Hugenholtz, Floor; Belzer, Clara; Vos, Willem M. de; Wiersinga, W.J.
Source Journal of Antimicrobial Chemotherapy 74 (2019)3. - ISSN 0305-7453 - p. 782 - 786.
DOI https://doi.org/10.1093/jac/dky471
Department(s) MolEco
VLAG
Microbiology
WIMEK
Publication type Refereed Article in a scientific journal
Publication year 2019
Abstract

OBJECTIVES: The impact of combination antibiotic therapy on the composition of the intestinal microbiota remains ill-defined. We aimed to assess the effect of a 1 week antibiotic regimen on the intestinal microbiota of healthy humans for a period of up to 31 months. PATIENTS AND METHODS: Thirteen healthy adult men received either no treatment or oral broad-spectrum antibiotics (ciprofloxacin, vancomycin and metronidazole) for 7 days. At four timepoints (prior to treatment, on day 9, day 49 and 8-31 months later) faecal samples were collected and analysed using 16S RNA gene sequencing. RESULTS: The short-term impact of broad-spectrum antibiotics on the gut microbiota was profound, with a loss of diversity and drastic shifts in community composition. In addition, antibiotics significantly reduced the abundance of bacterial taxa with important metabolic functions, such as the production of butyrate. The microbiota showed a remarkable return towards baseline after 8-31 months, but community composition often remained altered from its initial state. CONCLUSIONS: These findings suggest that combined treatment with vancomycin, ciprofloxacin and metronidazole has a profound and long-lasting effect on microbiota composition, the consequences of which remain largely unknown.

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