Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 548382
Title Dystrophin is required for normal synaptic gain in the Drosophila olfactory circuit
Author(s) Jantrapirom, Salinee; Cao, De Shou; Wang, Jing W.; Hing, Huey; Tabone, Christopher J.; Lantz, Kathryn; Belle, J.S. de; Qiu, Yu Tong; Smid, Hans M.; Yamaguchi, Masamitsu; Fradkin, Lee G.; Noordermeer, Jasprina N.; Potikanond, Saranyapin
Source Brain Research 1712 (2019). - ISSN 0006-8993 - p. 158 - 166.
DOI https://doi.org/10.1016/j.brainres.2019.01.039
Department(s) Business Development
OT Team Schimmels Onkr. en Plagen
Laboratory of Entomology
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Antennal lobe - Behavior - Drosophila melanogaster - Dystrophin - Olfaction - Olfactory receptor neurons - Projection neurons
Abstract

The Drosophila olfactory system provides an excellent model to elucidate the neural circuits that control behaviors elicited by environmental stimuli. Despite significant progress in defining olfactory circuit components and their connectivity, little is known about the mechanisms that transfer the information from the primary antennal olfactory receptor neurons to the higher order brain centers. Here, we show that the Dystrophin Dp186 isoform is required in the olfactory system circuit for olfactory functions. Using two-photon calcium imaging, we found the reduction of calcium influx in olfactory receptor neurons (ORNs) and also the defect of GABA A mediated inhibitory input in the projection neurons (PNs) in Dp186 mutation. Moreover, the Dp186 mutant flies which display a decreased odor avoidance behavior were rescued by Dp186 restoration in the Drosophila olfactory neurons in either the presynaptic ORNs or the postsynaptic PNs. Therefore, these results revealed a role for Dystrophin, Dp 186 isoform in gain control of the olfactory synapse via the modulation of excitatory and inhibitory synaptic inputs to olfactory projection neurons.

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