Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 549639
Title Multicore Liquid Perfluorocarbon-Loaded Multimodal Nanoparticles for Stable Ultrasound and 19F MRI Applied to In Vivo Cell Tracking
Author(s) Koshkina, Olga; Lajoinie, Guillaume; Baldelli Bombelli, Francesca; Swider, Edyta; Cruz, Luis J.; White, Paul B.; Schweins, Ralf; Dolen, Yusuf; Dinther, Eric A.W. van; Riessen, N.K. van; Rogers, Sarah E.; Fokkink, Remco; Voets, Ilja K.; Eck, Ernst R.H. van; Heerschap, Arend; Versluis, Michel; Korte, Chris L. de; Figdor, Carl G.; Vries, I.J.M. de; Srinivas, Mangala
Source Advanced Functional Materials 29 (2019)19. - ISSN 1616-301X
DOI https://doi.org/10.1002/adfm.201806485
Department(s) Physical Chemistry and Soft Matter
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) F MRI - cell therapy - cell tracking - multimodal imaging - perfluorocarbons - ultrasound
Abstract

Ultrasound is the most commonly used clinical imaging modality. However, in applications requiring cell-labeling, the large size and short active lifetime of ultrasound contrast agents limit their longitudinal use. Here, 100 nm radius, clinically applicable, polymeric nanoparticles containing a liquid perfluorocarbon, which enhance ultrasound contrast during repeated ultrasound imaging over the course of at least 48 h, are described. The perfluorocarbon enables monitoring the nanoparticles with quantitative 19 F magnetic resonance imaging, making these particles effective multimodal imaging agents. Unlike typical core–shell perfluorocarbon-based ultrasound contrast agents, these nanoparticles have an atypical fractal internal structure. The nonvaporizing highly hydrophobic perfluorocarbon forms multiple cores within the polymeric matrix and is, surprisingly, hydrated with water, as determined from small-angle neutron scattering and nuclear magnetic resonance spectroscopy. Finally, the nanoparticles are used to image therapeutic dendritic cells with ultrasound in vivo, as well as with 19 F MRI and fluorescence imaging, demonstrating their potential for long-term in vivo multimodal imaging.

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