Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 549998
Title Reassortments among avian influenza A(H5N1) viruses circulating in Indonesia, 2015-2016
Author(s) Karo-Karo, Desniwaty; Bodewes, Rogier; Wibawa, Hendra; Artika, I.M.; Pribadi, Eko Sugeng; Diyantoro, D.; Pratomo, Widya; Sugama, Agus; Hendrayani, Nani; Indasari, Iin; Wibowo, Michael Haryadi; Muljono, David Handojo; Stegeman, Jan Arend; Koch, Guus
Source Emerging Infectious Diseases 25 (2019)3. - ISSN 1080-6040 - p. 465 - 472.
DOI https://doi.org/10.3201/eid2503.180167
Department(s) Virology
Publication type Refereed Article in a scientific journal
Publication year 2019
Abstract

Highly pathogenic avian influenza (HPAI) A(H5N1) viruses have been circulating since 2003 in Indonesia, with major impacts on poultry health, severe economic losses, and 168 fatal laboratory-confirmed human cases. We performed phylogenetic analysis on 39 full-genome H5N1 virus samples collected during outbreaks among poultry in 2015-2016 in West Java and compared them with recently published sequences from Indonesia. Phylogenetic analysis revealed that the hemagglutinin gene of all samples belonged to 2 genetic groups in clade 2.3.2.1c. We also observed these groups for the neuraminidase, nucleoprotein, polymerase, and polymerase basic 1 genes. Matrix, nonstructural protein, and polymerase basic 2 genes of some HPAI were most closely related to clade 2.1.3 instead of clade 2.3.2.1c, and a polymerase basic 2 gene was most closely related to Eurasian low pathogenicity avian influenza. Our results detected a total of 13 reassortment types among HPAI in Indonesia, mostly in backyard chickens in Indramayu.

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