Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 550061
Title Reconstructing functional networks in the human intestinal tract using synthetic microbiomes
Author(s) Shetty, Sudarshan A.; Smidt, Hauke; Vos, Willem M. de
Source Current Opinion in Biotechnology 58 (2019). - ISSN 0958-1669 - p. 146 - 154.
DOI https://doi.org/10.1016/j.copbio.2019.03.009
Department(s) MolEco
WIMEK
VLAG
Microbiology
Publication type Refereed Article in a scientific journal
Publication year 2019
Abstract

The human intestinal tract harbors one of the most densely populated and open microbial ecosystems. The application of multi-omics approaches has provided insight into a wide array of complex interactions between the various groups of mainly anaerobic colonic microbes as well as the host–microbe dialogue. Integration of multi-omics techniques in cultivation based experiments that vary in complexity from monocultures to synthetic microbial communities identified key metabolic players in the trophic interactions as well as their ecological dynamics. A synergy between these approaches will be of utmost importance to reconstruct the functional interaction networks at the ecosystem level within the human intestinal microbiome. The improved understanding of microbiome functioning at ecosystem level will further aid in developing better predictive models and design of effective microbiome modulation strategies for health benefits.

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