Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 550311
Title Protein intake and the incidence of pre-diabetes and diabetes in 4 population-based studies: the PREVIEW project
Author(s) Sluik, D.; Brouwer, E.M.; Berendsen, A.M.; Mikkilä, V.; Poppitt, Sally D.; Silvestre, Marta P.; Tremblay, A.; Perusse, L.; Bouchard, C.; Raben, Anne; Feskens, E.J.M.
Source American Journal of Clinical Nutrition 109 (2019)5. - ISSN 0002-9165 - p. 1310 - 1318.
DOI https://doi.org/10.1093/ajcn/nqy388
Department(s) Global Nutrition
VLAG
Human Nutrition & Health
Publication type Refereed Article in a scientific journal
Publication year 2019
Abstract Background:Data on the relationship between protein intake andthe risk of type 2 diabetes are conflicting.Objectives:We studied prospective associations between the intakeof total, plant-based, and animal protein and the risk of pre-diabetesand diabetes in 4 population-based studies included in the PREVIEWproject.Methods:Analyses were conducted with the use of data from 3 Eu-ropean cohorts and 1 Canadian cohort, including 78,851 participants.Protein intake was assessed through the use of harmonized datafrom food-frequency questionnaires or 3-d dietary records. Cohort-specific incidence ratios (IRs) were estimated for pre-diabetes anddiabetes, adjusting for general characteristics, lifestyle and dietaryfactors, disease history, and body mass index (BMI) and waistcircumference; results were pooled based on a random-effects meta-analysis.Results:Higher total protein intake (g·kg–1·d–1) was associatedwith lower incidences of pre-diabetes and diabetes (pooled IRs: 0.84;95% CI: 0.82, 0.87 and 0.49; 95% CI: 0.28, 0.83, respectively); plant-based protein intake was the main determinant (pooled IRs: 0.83;95% CI: 0.81, 0.86 and 0.53; 95% CI: 0.36, 0.76, respectively).Substituting 2 energy percentage (E%) protein at the expense ofcarbohydrates revealed increased risks of pre-diabetes and diabetes(pooled IRs: 1.04; 95% CI: 1.01, 1.07 and 1.09; 95% CI: 1.01, 1.18,respectively). Except for the associations between intakes of totalprotein and plant-based protein (g·kg–1·d–1) and diabetes, all otherassociations became nonsignificant after adjustment for BMI andwaist circumference.Conclusions:Higher protein intake (g·kg–1·d–1) was associatedwith a lower risk of pre-diabetes and diabetes. Associationswere substantially attenuated after adjustments for BMI and waistcircumference, which demonstrates a crucial role for adiposityand may account for previous conflicting findings. This study wasregistered at ISRCTN as ISRCTN31174892.
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