Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 550656
Title Prebiotic oligosaccharides in early life alter gut microbiome development in male mice while supporting influenza vaccination responses
Author(s) Elsen, L.W.J. van den; Tims, S.; Jones, A.M.; Stewart, A.; Stahl, B.; Garssen, J.; Knol, J.; Forbes-Blom, E.E.; van’t Land, B.
Source Beneficial Microbes 10 (2019)3. - ISSN 1876-2883 - p. 279 - 291.
Department(s) Dierverzorging en Biotechniek
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Antibody - Gender - HMOS - Microbiota - TIV

Beneficial modulation of the gut microbiota is an attractive therapeutic approach to improve the efficacy of vaccine-induced immunity. In this study, mice were supplemented with the prebiotic milk oligosaccharide 2’-fucosyllactose (2’FL) as well as a complex mixture of immune modulatory prebiotic short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS) from different stages in early life. Adult mice were vaccinated with trivalent influenza vaccine (TIV) and both development of the gut microbiota and antibody-mediated vaccine responses were followed over time. Within the control group, female mice demonstrated a larger antibody response to TIV vaccination than male mice, which was accompanied by enhanced cytokine production by splenocytes and a higher percentage of plasma cells in skin draining lymph nodes. In addition, the prebiotic diet improved vaccine-specific antibody responses in male mice. Introduction of prebiotics into the diet modulated the gut microbiota composition and at the genus level several bacterial groups showed a significant interaction effect which potentially contributed to the immunological effects observed. This study provides insight in the effect of scGOS/lcFOS/2’FL in influenza vaccination antibody production.

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