Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 550694
Title Metabolomics in systems medicine: an overview of methods and applications
Author(s) Karakitsou, Effrosyni; Foguet, Carles; Atauri, Pedro de; Kultima, Kim; Khoonsari, Payam Emami; Martins dos Santos, Vitor A.P.; Saccenti, Edoardo; Rosato, Antonio; Cascante, Marta
Source Current Opinion in Systems Biology 15 (2019). - ISSN 2452-3100 - p. 91 - 99.
Department(s) VLAG
Systems and Synthetic Biology
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Constraint-based modelling - Kinetic modellig - Metabolomics - Multiomics - Personalized medicine - Systems medicine

Patient-derived metabolomics offers valuable insights into the metabolic phenotype underlying diseases with a strong metabolic component. Thus, these data sets will be pivotal to the implementation of personalized medicine strategies in health and disease. However, to take full advantage of such data sets, they must be integrated with other omics within a coherent pathophysiological framework to enable improved diagnostics, to identify therapeutic interventions, and to accurately stratify patients. Herein, we provide an overview of the state-of-the-art data analysis and modeling approaches applicable to metabolomics data and of their potential for systems medicine.

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