Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 550903
Title A single meal containing phytosterols does not affect the uptake or tissue distribution of cholesterol in zebrafish (Danio rerio)
Author(s) Spankeren, Michel van; Sibinga, Nathaniel; Reinshol, Øyvind; Torstensen, Bente E.; Sæle, Øystein; Liland, Nina S.
Source Frontiers in Marine Science 6 (2019). - ISSN 2296-7745
DOI https://doi.org/10.3389/fmars.2019.00092
Department(s) Aquaculture and Fisheries
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Aquaculture - Cholesterol - Cholesterol uptake - Phytosterols - Zebrafish
Abstract

Increased plant oil inclusion in aquaculture feeds has led to higher dietary phytosterol concentrations and speculation about whether this affects the metabolism and health of the fish. The mechanisms of cholesterol absorption and how phytosterols may affect this is unknown in fish. Zebrafish (Danio rerio) were used to study the effects of phytosterols on the uptake and organ distribution of dietary cholesterol in fish. One meal of diets containing a constant addition of cholesterol (cold and [4- 14 C] cholesterol) and varying types and concentrations of phytosterols were fed to fish in individual compartments. The fish were not previously conditioned on the experimental diets. Activity of 14 C was then measured in water and fish tissues to quantify the tissue distribution and excretion of cholesterol. There were no effects of the moderate dietary concentrations of phytosterols on the excretion or tissue distribution of dietary cholesterol 24 h after the meal.

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