Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 551171
Title Novel approaches to derive points of departure for food chemical risk assessment
Author(s) Levorato, Sara; Rietjens, Ivonne M.C.M.; Carmichael, Paul L.; Hepburn, Paul A.
Source Current Opinion in Food Science (2019). - ISSN 2214-7993
DOI https://doi.org/10.1016/j.cofs.2019.02.016
Department(s) WIMEK
VLAG
Toxicology
Publication type Refereed Article in a scientific journal
Publication year 2019
Abstract

Food chemical risk assessment characterizes the potential hazards and the associated health risks resulting from exposure of humans to chemicals present in food over a specified period. This requires the identification of points of departure, which are usually derived from apical toxicity endpoints in in vivo studies. However, a shift in the traditional paradigm in toxicity testing for risk assessment has started, and increasing attention is now being paid to the use of mechanistic-based and exposure-based approaches, including toxicogenomics and quantitative in vitro-to-in vivo extrapolation. This review outlines the most recent examples of application of these new approaches to derive points of departure in food chemical risk assessment, as well as the challenges limiting their full application and future directions.

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