Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 551186
Title Mito-nuclear communication by mitochondrial metabolites and its regulation by B-vitamins
Author(s) Janssen, Joëlle J.E.; Grefte, Sander; Keijer, Jaap; Boer, Vincent C.J. De
Source Frontiers in Physiology 10 (2019)FEB. - ISSN 1664-042X
DOI https://doi.org/10.3389/fphys.2019.00078
Department(s) Human and Animal Physiology
WIAS
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Acyl-CoA - B-vitamins - Epigenetic modifications - Mito-nuclear signaling - Reactive oxygen species - Sirtuins - TCA cycle metabolites
Abstract

Mitochondria are cellular organelles that control metabolic homeostasis and ATP generation, but also play an important role in other processes, like cell death decisions and immune signaling. Mitochondria produce a diverse array of metabolites that act in the mitochondria itself, but also function as signaling molecules to other parts of the cell. Communication of mitochondria with the nucleus by metabolites that are produced by the mitochondria provides the cells with a dynamic regulatory system that is able to respond to changing metabolic conditions. Dysregulation of the interplay between mitochondrial metabolites and the nucleus has been shown to play a role in disease etiology, such as cancer and type II diabetes. Multiple recent studies emphasize the crucial role of nutritional cofactors in regulating these metabolic networks. Since B-vitamins directly regulate mitochondrial metabolism, understanding the role of B-vitamins in mito-nuclear communication is relevant for therapeutic applications and optimal dietary lifestyle. In this review, we will highlight emerging concepts in mito-nuclear communication and will describe the role of B-vitamins in mitochondrial metabolite-mediated nuclear signaling.

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