Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 551272
Title Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products
Author(s) Brouwer, Michael S.M.; Tehrani, Kamaleddin H.M.E.; Rapallini, Michel; Geurts, Yvon; Kant, Arie; Harders, Frank; Mashayekhi, Vida; Martin, Nathaniel I.; Bossers, Alex; Mevius, Dik J.; Wit, Ben; Veldman, Kees T.
Source Antimicrobial Agents and Chemotherapy 63 (2019)6. - ISSN 0066-4804
DOI https://doi.org/10.1128/AAC.02338-18
Department(s) Bacteriology & Epidemiology
Micro 3: Knowledge and Expertise
Infection Biology
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Antimicrobial resistance - Carbapenemase - Enterobacter - Plasmid
Abstract

Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A -lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined.

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