Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 551789
Title Keeping crispr in check: diverse mechanisms of phage-encoded anti-crisprs
Author(s) Trasanidou, Despoina; Gerós, Ana Sousa; Mohanraju, Prarthana; Nieuwenweg, Anna Cornelia; Nobrega, Franklin L.; Staals, Raymond H.J.
Source FEMS Microbiology Letters 366 (2019)9. - ISSN 0378-1097
DOI https://doi.org/10.1093/femsle/fnz098
Department(s) BacGen
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) crispr-cas - anti-crispr - genome editing - phage
Abstract CRISPR-Cas represents the only adaptive immune system of prokaryotes known to date. These immune systems are widespread among bacteria and archaea, and provide protection against invasion of mobile genetic elements, such as bacteriophages and plasmids. As a result of the arms-race between phages and their prokaryotic hosts, phages have evolved inhibitors known as anti-CRISPR (Acr) proteins to evade CRISPR immunity. In the recent years, several Acr proteins have been described in both temperate and virulent phages targeting diverse CRISPR-Cas systems. Here, we describe the strategies of Acr discovery and the multiple molecular mechanisms by which these proteins operate to inhibit CRISPR immunity. We discuss the biological relevance of Acr proteins and speculate on the implications of their activity for the development of improved CRISPR-based research and biotechnological tools.
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