Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 552020
Title Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy
Author(s) Hoppenbrouwers, Tamara; Cvejić Hogervorst, Jelena H.; Garssen, Johan; Wichers, Harry J.; Willemsen, Linette E.M.
Source Frontiers in Immunology 10 (2019). - ISSN 1664-3224 - 1 p.
DOI https://doi.org/10.3389/fimmu.2019.01118
Department(s) Food, Health & Consumer Research
Food Quality and Design
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) anti-inflammatory - food allergy - immune response - LCPUFA - PUFA
Abstract

N-3 long chain polyunsaturated fatty acids (LCPUFAs) are considered to possess protective properties for human health by impacting on immunological reactions. An "inflammation-suppressive" effect appears to be the common denominator of the beneficial effects of most of these dietary components which may protect against the development of chronic immune disorders such as (food) allergy. LCPUFAs, especially n-3 LCPUFAs, have been shown to interact with both the sensitization as well as the effector phase in food allergy in pre-clinical models. In this review, we explore the anti-allergic properties of LCPUFAs by providing an overview of clinical, in vivo and in vitro studies. Furthermore, we discuss the susceptibility of LCPUFAs to lipid oxidation and possible strategies to support the efficacy of LCPUFAs in reducing the allergy risk by using additional components with anti-oxidative and anti-inflammatory capacities such as the flavonoid quercetin. Finally, we propose new strategies to prevent (food) allergy using combinations of LCPUFAs and additional nutrients in diets or supplements, and postulate to investigate the use of LCPUFAs in allergic symptom relief.

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