Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 552059
Title Human respiratory syncytial virus infection in the pre-clinical calf model
Author(s) Cortjens, B.; Jong, R. de; Bonsing, J.G.; Woensel, J.B.M. van; Bem, R.A.; Antonis, A.F.G.
Source Comparative Immunology Microbiology and Infectious Diseases 65 (2019). - ISSN 0147-9571 - p. 213 - 218.
DOI https://doi.org/10.1016/j.cimid.2019.04.006
Department(s) Virology
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Animal model - Bronchiolitis - Calves - Neutrophil - Respiratory syncytial virus - Upper and lower respiratory tract infections
Abstract

Human respiratory syncytial virus (hRSV) is the most important respiratory pathogen in young children worldwide. Experimental modelling of hRSV disease by bovine RSV (bRSV) infection in calves provides an important tool for developing new strategies for prevention and treatment. Depending on the scientific hypothesis under investigation, this cognate host-virus model might have the disadvantage of using a highly related but not genetically identical virus. In this study, we aim to describe viral kinetics and (clinical) disease characteristics in calves inoculated with hRSV. Our results show that hRSV infects the upper and, to a lesser extent, the lower respiratory tract of calves. Infection causes upper airway clinical disease symptoms and neutrophilic infiltration of the lower airways. We conclude that a hRSV model in calves may aid future research involving distinct scientific questions related to hRSV disease in children.

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