|Title||Phylogenomic investigation of IncI1-I plasmids harboring blaCMY-2 and blaSHV-12 in salmonella enterica and Escherichia coli in multiple countries|
|Author(s)||Castellanos, Luis Ricardo; Graaf-Van Bloois, Linda van der; Donado-Godoy, Pilar; Mevius, Dik J.; Wagenaar, Jaap A.; Hordijk, Joost; Zomer, Aldert L.|
|Source||Antimicrobial Agents and Chemotherapy 63 (2019)7. - ISSN 0066-4804|
|Department(s)||Bacteriology & Epidemiology|
|Publication type||Refereed Article in a scientific journal|
|Keyword(s)||Blc - Broiler - Chicken - DeoR - IS1294 - IS26 - ISEcp1 - S. Heidelberg - Salmonella Paratyphi B var. Java - SugE - Tn1721|
The objective of this study was to elucidate the genetic and evolutionary relatedness of blaCMY-2- and blaSHV-12-carrying IncI1-I plasmids. Phylogenomic analysis based on core genome alignments and gene presence/absence was performed for different IncI1-I sequence types (STs). Most IncI1-I/ST12 and IncI1-I/ ST231 plasmids had near-identical core genomes. The data suggest that widely occurring blaCMY-2-carrying IncI1-I/ST12 plasmids originate from a common ancestor. In contrast, blaSHV-12 was inserted independently into different IncI1-I/ST231-related plasmids.