Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 553397
Title Genomic regions associated with IgE levels against culicoides spp. Antigens in three horse breeds
Author(s) François, Liesbeth; Hoskens, Hanne; Velie, Brandon D.; Stinckens, Anneleen; Tinel, Susanne; Lamberigts, Chris; Peeters, Liesbet; Savelkoul, Huub F.J.; Tijhaar, Edwin; Lindgren, Gabriella; Janssens, Steven; Ducro, Bart J.; Buys, Nadine; Schurink, Anouk
Source Genes 10 (2019)8. - ISSN 2073-4425
DOI https://doi.org/10.3390/genes10080597
Department(s) WIAS
Cell Biology and Immunology
Animal Breeding and Genomics
Animal Breeding & Genomics
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) Belgian Warmblood horse - Diagnostic ELISA test - Genome-wide association study - Icelandic horse - IgE - Insect bite hypersensitivity - Shetland pony - Summer eczema
Abstract

Insect bite hypersensitivity (IBH), which is a cutaneous allergic reaction to antigens from Culicoides spp., is the most prevalent skin disorder in horses. Misdiagnosis is possible, as IBH is usually diagnosed based on clinical signs. Our study is the first to employ IgE levels against several recombinant Culicoides spp. allergens as an objective, independent, and quantitative phenotype to improve the power to detect genetic variants that underlie IBH. Genotypes of 200 Shetland ponies, 127 Icelandic horses, and 223 Belgian Warmblood horses were analyzed while using a mixed model approach. No single-nucleotide polymorphism (SNP) passed the Bonferroni corrected significance threshold, but several regions were identified within and across breeds, which confirmed previously identified regions of interest and, in addition, identifying new regions of interest. Allergen-specific IgE levels are a continuous and objective phenotype that allow for more powerful analyses when compared to a case-control set-up, as more significant associations were obtained. However, the use of a higher density array seems necessary to fully employ the use of IgE levels as a phenotype. While these results still require validation in a large independent dataset, the use of allergen-specific IgE levels showed value as an objective and continuous phenotype that can deepen our understanding of the biology underlying IBH.

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