Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 553590
Title The effect of an encapsulated nutrient mixture on food intake and satiety : A double-blind randomized cross-over proof of concept study
Author(s) Alleleyn, Annick M.E.; Avesaat, Mark van; Ripken, Dina; Bleiel, Sinéad B.; Keszthelyi, Daniel; Wilms, Ellen; Troost, Freddy J.; Hendriks, Henk F.J.; Masclee, Adrian A.M.
Source Nutrients 10 (2018)11. - ISSN 2072-6643
Department(s) Human Nutrition & Health
Nationale Raad voor Landbouwkundig Onderzoek TNO
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Carbohydrate - Distal release - Encapsulated nutrient mixture - Overweight - Protein - Satiety - Weight management

Activation of the intestinal brake by infusing nutrients into the distal small intestine with catheters inhibits food intake and enhances satiety. Encapsulation of macronutrients, which protects against digestion in the proximal gastrointestinal tract, can be a non-invasive alternative to activate this brake. In this study, we investigate the effect of oral ingestion of an encapsulated casein and sucrose mixture (active) targeting the distal small intestine versus a control product designed to be released in the stomach on food intake, satiety, and plasma glucose concentrations. Fifty-nine volunteers received the active and control product on two separate test days. Food intake was determined during an ad libitum meal 90 min after ingestion of the test product. Visual analogue scale scores for satiety and blood samples for glucose analysis were collected at regular intervals. Ingestion of the active product decreased food intake compared to the control product (655 kcal compared with 699 kcal, respectively, p < 0.05). The area under the curve (AUC) for hunger was decreased (p < 0.05) and AUC for satiety was increased (p < 0.01) after ingestion of the active product compared to the control product. Ingestion of an encapsulated protein-carbohydrate mixture resulted in inhibition of food intake compared to a non-encapsulated control product.

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