Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 553900
Title Virus Shedding of Avian Influenza in Poultry: A Systematic Review and Meta-Analysis
Author(s) Germeraad, Evelien A.; Sanders, Pim; Hagenaars, Thomas J.; Jong, Mart C.M. de; Beerens, Nancy; Gonzales, Jose L.
Source Viruses 11 (2019)9. - ISSN 1999-4915
DOI https://doi.org/10.3390/v11090812
Department(s) Virology
Bacteriology & Epidemiology
WIAS
Quantitative Veterinary Epidemiology
Publication type Refereed Article in a scientific journal
Publication year 2019
Keyword(s) avian influenza - meta-analysis - poultry - systematic review - virus shedding
Abstract

Understanding virus shedding patterns of avian influenza virus (AIV) in poultry is important for understanding host-pathogen interactions and developing effective control strategies. Many AIV strains were studied in challenge experiments in poultry, but no study has combined data from those studies to identify general AIV shedding patterns. These systematic review and meta-analysis were performed to summarize qualitative and quantitative information on virus shedding levels and duration for different AIV strains in experimentally infected poultry species. Methods were designed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Four electronic databases were used to collect literature. A total of 1155 abstract were screened, with 117 studies selected for the qualitative analysis and 71 studies for the meta-analysis. A large heterogeneity in experimental methods was observed and the quantitative analysis showed that experimental variables such as species, virus origin, age, inoculation route and dose, affect virus shedding (mean, peak and duration) for highly pathogenic AIV (HPAIV), low pathogenic AIV (LPAIV) or both. In conclusion, this study highlights the need to standardize experimental procedures, it provides a comprehensive summary of the shedding patterns of AIV strains by infected poultry and identifies the variables that influence the level and duration of AIV shedding.

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