Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 554025
Title Fasting-induced adipose factor/ angiopoietin-like protein 4 as an adipokine
Author(s) Kersten, Sander
Source In: Adipokines / Preedy, V.R., Hunter, R.J., CRC Press - ISBN 9781138114418 - p. 60 - 67.
Department(s) VLAG
Nutrition, Metabolism and Genomics
Publication type Peer reviewed book chapter
Publication year 2016
Abstract

The adipose tissue serves as a major endocrine organ by secreting a large number of metabolically and/or immunologically active factors. One of the proteins secreted by adipose and other tissues is fasting-induced adipose factor (FIAF)/ angiopoietin-like protein 4 (Angptl4), a member of the family of angiopoietins and angiopoietin-like protein. Angptl4 forms higher order oligomers and upon secretion undergoes proteolytic processing to yield N- and C-terminal fragments. The best-characterized function of Angptl4 is as inhibitor of the enzyme lipoprotein lipase, leading to decreased clearance of plasma triglycerides. Additionally, Angptl4 promotes adipose tissue lipolysis. Data suggest that Angptl4 is retained in the extracellular matrix and governs angiogenesis by influencing the function of endothelial cells. Expression of Angptl4 is stimulated by fatty acids via peroxisome proliferator-activated receptors and by hypoxia via hypoxia-inducible factor 1 alpha. In conclusion, Angptl4 is an adipokine with several biological activities with major impact on lipid metabolism.

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