Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 554038
Title Genetic variants determining survival and fertility in an adverse African environment: A population-based large-scale candidate gene association study
Author(s) Koopman, Jacob J.E.; Pijpe, Jeroen; Böhringer, Stefan; Bodegom, David van; Eriksson, Ulrika K.; Sanchez-Faddeev, Hernando; Ziem, Juventus B.; Zwaan, Bas; Eline Slagboom, P.; Knijff, Peter de; Westendorp, Rudi G.J.
Source Aging-US 8 (2016)7. - ISSN 1945-4589 - p. 1364 - 1383.
DOI https://doi.org/10.18632/aging.100986
Department(s) PE&RC
Laboratory of Genetics
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Africa - Aging - Evolution - Fertility - Gene - Human - Life history - SNP - Survival
Abstract

Human survival probability and fertility decline strongly with age. These life history traits have been shaped by evolution. However, research has failed to uncover a consistent genetic determination of variation in survival and fertility. As an explanation, such genetic determinants have been selected in adverse environments, in which humans have lived during most of their history, but are almost exclusively studied in populations in modern affluent environments. Here, we present a large-scale candidate gene association study in a rural African population living in an adverse environment. In 4387 individuals, we studied 4052 SNPs in 148 genes that have previously been identified as possible determinants of survival or fertility in animals or humans. We studied their associations with survival comparing newborns, middle-age adults, and old individuals. In women, we assessed their associations with reported and observed numbers of children. We found no statistically significant associations of these SNPs with survival between the three age groups nor with women's reported and observed fertility. Population stratification was unlikely to explain these results. Apart from a lack of power, we hypothesise that genetic heterogeneity of complex phenotypes and gene -environment interactions prevent the identification of genetic variants explaining variation in survival and fertility in humans.

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